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4-AcO-DMT, AKA synthetic shrooms  is a prodrug of a psychoactive ingredient in magic mushrooms (psilocin).

The experience is virtually indistinguishable from the effects of magic mushrooms, aside from a few subtle subjective differences.

The patents for this tried and tested compound expired decades ago - threatening the work companies like Compass Pathways are doing to monopolize the synthetic psilocybin market over the next 20 years.

Here’s everything you should know about 4-AcO-DMT.

What is 4-AcO-DMT?

4-AcO-DMT stands for 4-Acetoxy-DMT. It was invented by Albert Hofmann - the same person who invented LSD (lysergic acid diethylamide) - and his colleague Franz Troxler. It was invented in the early 60s as part of the duo’s exploration of the active ingredients in psychedelic mushrooms.

4-AcO-DMT is a derivative of psilocin - which is the main pharmacological component of magic mushrooms. Both psilocybin and 4-AcO-DMT are converted to psilocin by the liver, which then provides the psychoactive effects.

As such, the effects of 4-AcO-DMT are virtually identical to that of psilocybin or psilocin.

The company the team was working for - Sandoz - filed for a patent in January of 1963 but never got a chance to exploit it for any profit. They simply didn’t know what to do with this or any of Hofmann’s psychoactive substances (including LSD and psilocybin).

This all took place just shortly after the Harvard Psilocybin project - which was run by Timothy Leary and Richard Alpert. Sandoz was giving Leary large quantities of LSD for the sake of studying it in search of potential lucrative applications in the field of psychotherapy.

4-AcO-DMT was shelved for several decades until the late 90s when a man by the name of David E. Nichols began campaigning for the use of the substance in psychedelic-assisted psychotherapy. He aimed to motivate researchers to take a closer look at this compound so it could eventually make its way into the medical system. Nichols favored it for its reliability of effects, cost-effectiveness, and sheer potency.

Unfortunately, there has yet to be a single clinical study on the effects of 4-AcO-DMT. Most of the information currently available comes to us from animal studies and anecdotal reports.

Despite how poorly this drug has been studied, 4-AcO-DMT is one of the most popular synthetic psychedelics, falling behind LSD and ketamine but higher than 2C-B, Dipt, or other drugs in the 2C-X family.

4-AcO-DMT is a whitish brown powder in its raw form, most often sold in capsules or tablets.

What Does 4-AcO-DMT Feel Like?

In general, 4-AcO-DMT mimics the effects of psilocybin mushrooms. The active ingredient isn’t the 4-AcO-DMT itself - but its primary metabolite, psilocin. This makes 4-AcO-DMT a prodrug of the naturally occurring psychedelic, psilocin.

In lower doses (up to 30 mg), 4-AcO-DMT and magic mushrooms are virtually indistinguishable. It produces auditory and visual hallucinations, enhances introspection and existential thought processes, suppresses the default mode network (DMN), and alters the perception of time and sensory information.

In higher doses (over 30 mg), the effects of 4-AcO-DMT begin to change. This dose is very powerful and is much more similar to DMT. The visuals become much more fractal and geometric, and the hallucinations and sense of empathy and introspection become very intense.

The existential weight of this substance, especially in higher doses, is one of the main reasons why so many people only use this drug once. High doses of 4-AcO-DMT are much more likely to cause terrifying or uncomfortable trips than high doses of magic mushrooms, but it isn’t clear why this is the case.

Through our trip surveys, we’ve received 11 reports of people using 4-AcO-DMT. Most people took between 20 and 30 mg and reported the effects to be very similar to magic mushrooms but a bit mellower.

Common Reported Effects from 4-AcO-DMT:

• Introspection

• Altered perception of time

• Fractal geometric patterns

• The perception of music changes, sometimes for worse, sometimes better

• Full-body floating sensation

• Euphoria

• Ego-dissociation

How Long Does 4-AcO-DMT Last?

One of the main differences between 4-AcO-DMT and shrooms is the duration of effects. This substance can last anywhere from 2 to 6 hours. Only in very rare cases does it last a full 8 hours like magic mushrooms.

If you take 4-AcO-DMT on an empty stomach or snort the powder rather than consume it as a capsule, the effects are going to begin and end sooner.

For example, if you take 4-AcO-DMT in capsule form, expect it to take up to 45 minutes to start taking effect. Peak experience begins around the 2-hour mark, which gradually tapers off over the next 2–4 hours.

If you insufflate (snort) the powder, the effects come on within about 15 minutes, reach peak effect by the 1-hour mark, and taper off over the following 2 or 3 hours.

What’s the Dose of 4-AcO-DMT?

One of the main advantages of 4-AcO-DMT, and the reason why people like David Nicoles are so supportive of this substance is its reliability of effects.

Since this is a pure compound with a fast and predictable metabolism, the potency of effects is much easier to gauge than the more natural psychedelics. Plants and fungi are harder to dose because the concentration of active ingredients can vary widely from one sample to the next.

The general dose of 4-AcO-DMT ranges from 10 to 30 mg. Some people take less (microdose), others take more (heroic dose). A 20 mg dose is roughly equivalent (subjectively) to 3 grams of dried psilocybin mushrooms.

If you’re new to using 4-AcO-DMT, it’s wise to start on the low-end of the spectrum and increase gradually over time.

The type of 4 AcO DMT has a slight impact on the dose. For example, if using 4 AcO DMT fumarate salt, you need about 1.24 mg of powder. If using 4 AcO DMT hydrochloride salt, you need a bit less, at 1.15 mg of powder. The dose is also about 20% lower if insufflating the active ingredients rather than consuming them orally.

Here’s some general dosage information to get you started:

• Microdose — 1–2 mg

• Threshold Dose — 5 mg

• Light Dose — 10 – 20 mg

• Standard Dose — 20–30 mg

• Heroic Dose — 40+ mg